There's a good chance that you'll see Travis Kelce out of uniform this week, though he won't be hanging out with George Kittle as he was here in this picture.
Allen Robinson didn't need any help, but the tanking Jaguars look poised to give it to him anyway as the Bears head to Jacksonville.
The Bears struggled against Justin Jefferson the first time around, and they might have a rough go of it again potentially down two of their top three cornerbacks Sunday.
Beast or not, DeAndre Hopkins might have some trouble against James Bradberry, especially as defenses increasingly catch on to Arizona's static route combinations.
The Packers might not need him much to secure the victory, but if they look to Allen Lazard he will pose a big mismatch against Philadelphia's tiny corners.
It's been a disappointing season for Marquise Brown and the Ravens offense, but Brown might not see an easier matchup all year than the Titans defense.
It's been a disheartening season for the Giants offense, but they might get on track as Darius Slayton and company take on a struggling Dallas secondary.
The Panthers have largely foregone the slot corner position in two games, choosing to cover with linebackers and safeties -- a potentially risky strategy against Keenan Allen.
While Russell Wilson, Dak Prescott and Kyler Murray are getting all the attention, a matchup between the Bengals and Eagles also offers shootout potential.
Jerick McKinnon may not come with assurances in terms of rushing workload, but his role in the passing game should make him a solid Week 3 start even if he get only 8-10 carries.
Will Fuller's breakout season may yet resume, but a matchup with the Baltimore corner rotation is a good way to briefly derail it.
No matter whether he runs more from the slot or out wide, it's difficult to see what the Raiders corners can do to slow down D.J. Moore.
Jerry Donabedian discusses his weekly streaming strategy and identifies the Eagles defense as the top choice for Week 1.
Top-to-bottom, the Eagles' roster is bristling with talent. Coach Doug Pederson will attempt to work magic similar to the team's 2017 run to the Super Bowl.
In 2019, coach Sean McVay couldn't lead the Rams to the heights of his first two seasons. While key players are elsewhere, enough familiar faces are around to pull off a reasonable imitation of previous squads.
Keep track of the free agency developments and the fantasy repercussions they carry.
AJ Brown and the Titans need to win, and the Texans don't have much reason to put up a fight.
With Tampa Bay's top corner questionable with an ankle issue, DeAndre Hopkins is in position to deliver for his owners in Championship Week.