Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
James Cook struggled against the Chargers on Saturday, but he dominated Buffalo's backfield snaps and touches to an extent previously unseen this season.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
Amon-Ra St. Brown and the Lions receivers project for a substantial advantage against the Chicago secondary.
The Packers defense struggles with fundamentals and might have a difficult game against Miami.
Juan Carlos Blanco tackles a Week 13 injury report that's loaded with major names at a critical time of the fantasy season and dishes out the latest information as of early Sunday morning.
With Josh Jacobs and Joe Mixon listed as questionable ahead of late kickoffs, it's unclear if Zamir White and Samaje Perine will be startable in fantasy leagues,
Erik Siegrist analyzes the Monday night matchup as Tom Brady and the Bucs take on the Saints in a key NFC South showdown.
Terry McLaurin should stay hot in an indoor game against a Houston defense that lacks speed.
Xavien Howard is more of a ballhawk than a shutdown corner, so Amari Cooper should do well in the warm weather Sunday.
Sauce Gardner vs. Stefon Diggs would be an interesting matchup, but the Bills should be able to keep Diggs away from Gardner.
Erik Siegrist analyzes the Monday night matchup as Daniel Jones leads the Giants against the Cowboys.